Drug Interactions
236 interaction pairs, each with the mechanism, how serious it is and what to do about it. The same records drive the safety engine that marks prescriptions inside Oskela.
Contraindicated15
Do not co-prescribe. The combination is unsafe whatever the indication.
- apixaban and dabigatran
- clarithromycin and amiodarone
- clarithromycin and simvastatin
- escitalopram and linezolid
- febuxostat and azathioprine
- fluoxetine and linezolid
- linezolid and sertraline
- methotrexate and co-trimoxazole
- metoclopramide and co-beneldopa
- prochlorperazine and co-beneldopa
- simvastatin and cyclosporine
- simvastatin and erythromycin
- spironolactone and potassium chloride
- valproic acid and meropenem
- warfarin and apixaban
Major192
Avoid where possible. If it cannot be avoided, adjust the dose and monitor closely.
- allopurinol and azathioprine
- amiodarone and atorvastatin
- amiodarone and azithromycin
- amiodarone and bisoprolol
- amiodarone and carvedilol
- amiodarone and ciprofloxacin
- amiodarone and diltiazem
- amiodarone and methadone
- amiodarone and metoprolol
- amiodarone and warfarin
- amitriptyline and fluoxetine
- amlodipine and cyclosporine
- apixaban and aspirin
- apixaban and clarithromycin
- apixaban and clopidogrel
- apixaban and naproxen
- apixaban and phenytoin
- aspirin and clopidogrel
- aspirin and prasugrel
- aspirin and ticagrelor
- atorvastatin and clarithromycin
- atorvastatin and cyclosporine
- atorvastatin and erythromycin
- azathioprine and trimethoprim
- bisoprolol and diltiazem
- bisoprolol and verapamil
- carbamazepine and clarithromycin
- carbamazepine and ethinylestradiol/levonorgestrel
- carbamazepine and fluoxetine
- carbamazepine and lamotrigine
- carbamazepine and simvastatin
- carbamazepine and theophylline
- carbamazepine and valproic acid
- carvedilol and salbutamol
- carvedilol and verapamil
- citalopram and aspirin
- citalopram and tramadol
- clarithromycin and cyclosporine
- clarithromycin and dabigatran
- clarithromycin and tacrolimus
- clopidogrel and esomeprazole
- clopidogrel and ibuprofen
- clopidogrel and omeprazole
- clozapine and fluoxetine
- colchicine and clarithromycin
- colchicine and simvastatin
- cyclosporine and diltiazem
- cyclosporine and erythromycin
- cyclosporine and fluconazole
- cyclosporine and ibuprofen
- cyclosporine and rifampicin
- dabigatran and amiodarone
- dabigatran and aspirin
- dabigatran and clopidogrel
- dabigatran and naproxen
- dabigatran and verapamil
- diclofenac and aspirin
- diclofenac and lisinopril
- digoxin and amiodarone
- digoxin and clarithromycin
- digoxin and erythromycin
- digoxin and furosemide
- digoxin and hydrochlorothiazide
- digoxin and ibuprofen
- digoxin and prednisolone
- digoxin and quinine
- digoxin and spironolactone
- digoxin and verapamil
- diltiazem and apixaban
- diltiazem and atorvastatin
- diltiazem and carvedilol
- diltiazem and digoxin
- edoxaban and aspirin
- edoxaban and clarithromycin
- edoxaban and clopidogrel
- enoxaparin and aspirin
- erythromycin and carbamazepine
- escitalopram and aspirin
- escitalopram and tramadol
- fluconazole and carbamazepine
- fluconazole and glibenclamide
- fluconazole and phenytoin
- fluoxetine and ibuprofen
- fluoxetine and risperidone
- fluoxetine and sumatriptan
- fluoxetine and tramadol
- fluoxetine and warfarin
- furosemide and ibuprofen
- gentamicin and furosemide
- gentamicin and vancomycin
- gliclazide and fluconazole
- ibuprofen and apixaban
- ibuprofen and dabigatran
- ibuprofen and lisinopril
- ibuprofen and perindopril
- ibuprofen and prednisolone
- ibuprofen and ramipril
- ibuprofen and spironolactone
- lisinopril and potassium chloride
- lisinopril and spironolactone
- lisinopril and trimethoprim
- lithium and bendroflumethiazide
- lithium and diclofenac
- lithium and furosemide
- lithium and hydrochlorothiazide
- lithium and ibuprofen
- lithium and lisinopril
- lithium and naproxen
- methadone and carbamazepine
- methadone and diazepam
- methadone and efavirenz
- methadone and phenytoin
- methotrexate and amoxicillin
- methotrexate and aspirin
- methotrexate and diclofenac
- methotrexate and fluconazole
- methotrexate and ibuprofen
- methotrexate and naproxen
- methotrexate and omeprazole
- methotrexate and probenecid
- methotrexate and trimethoprim
- metoprolol and diltiazem
- metoprolol and verapamil
- morphine and diazepam
- perindopril and diclofenac
- perindopril and spironolactone
- phenytoin and carbamazepine
- phenytoin and fluoxetine
- phenytoin and isoniazid
- phenytoin and rifampicin
- phenytoin and theophylline
- phenytoin and valproic acid
- propranolol and diltiazem
- propranolol and insulin human
- propranolol and salbutamol
- ramipril and diclofenac
- ramipril and losartan
- ramipril and potassium chloride
- ramipril and spironolactone
- rifampicin and ethinylestradiol/levonorgestrel
- rifampicin and methadone
- rivaroxaban and aspirin
- rivaroxaban and carbamazepine
- rivaroxaban and clarithromycin
- rivaroxaban and clopidogrel
- rivaroxaban and diclofenac
- rivaroxaban and ibuprofen
- rosuvastatin and cyclosporine
- sertraline and aspirin
- sertraline and ibuprofen
- sertraline and sumatriptan
- sertraline and tramadol
- simvastatin and amiodarone
- simvastatin and amlodipine
- simvastatin and diltiazem
- simvastatin and fluconazole
- simvastatin and verapamil
- spironolactone and trimethoprim
- tacrolimus and diltiazem
- tacrolimus and fluconazole
- tacrolimus and ibuprofen
- tacrolimus and rifampicin
- tacrolimus and verapamil
- tamoxifen and fluoxetine
- theophylline and ciprofloxacin
- theophylline and clarithromycin
- theophylline and erythromycin
- ticagrelor and simvastatin
- tramadol and linezolid
- valproic acid and aspirin
- valproic acid and lamotrigine
- warfarin and aspirin
- warfarin and azithromycin
- warfarin and carbamazepine
- warfarin and ciprofloxacin
- warfarin and clarithromycin
- warfarin and clopidogrel
- warfarin and dabigatran
- warfarin and diclofenac
- warfarin and erythromycin
- warfarin and flucloxacillin
- warfarin and fluconazole
- warfarin and ibuprofen
- warfarin and levofloxacin
- warfarin and levothyroxine
- warfarin and metronidazole
- warfarin and naproxen
- warfarin and phenytoin
- warfarin and prednisolone
- warfarin and rifampicin
- warfarin and sulfasalazine
- warfarin and trimethoprim
Moderate28
Usually manageable with monitoring or a dose change, but it must be recognised.
- amiodarone and apixaban
- amiodarone and levothyroxine
- citalopram and ibuprofen
- digoxin and bisoprolol
- digoxin and carvedilol
- digoxin and metoprolol
- digoxin and salbutamol
- diltiazem and dabigatran
- doxazosin and amlodipine
- fluconazole and atorvastatin
- fluoxetine and clopidogrel
- fluoxetine and olanzapine
- gliclazide and ramipril
- ibuprofen and aspirin
- levothyroxine and calcium carbonate
- levothyroxine and ferrous fumarate
- levothyroxine and ferrous sulfate
- levothyroxine and omeprazole
- metoprolol and salbutamol
- naproxen and lisinopril
- omeprazole and dabigatran
- phenytoin and omeprazole
- prednisolone and metformin
- salbutamol and bisoprolol
- theophylline and levofloxacin
- warfarin and amoxicillin
- warfarin and omeprazole
- warfarin and paracetamol
Minor1
Worth knowing, rarely changes the plan on its own.
Educational reference for students and clinicians in training. Always check current prescribing information before acting on an interaction.