Addisonian Crisis in a Patient with Vomiting and Fever
Write a prescription for addisonian crisis and have every line marked: drug choice, dose, route, frequency and duration, checked against the patient's allergies, current medicines, renal function and the interaction database, with each error explained.
medium8 scoring rules
- Patient
- 40 years, male, 75 kg
- Diagnosis
- Addisonian crisis
- Renal function
- eGFR 90 mL/min/1.73m²
- Allergies
- None known
- Current medicines
- hydrocortisone 10 mg in morning, 5 mg at midday and 5 mg in evening; fludrocortisone 0.1 mg once daily
The scenario
A 40-year-old man presents to the emergency department with a 24-hour history of vomiting and fever. He has known primary adrenal insufficiency (Addison's disease), diagnosed five years ago, and takes oral hydrocortisone 10 mg each morning, 5 mg at midday and 5 mg in the evening, with fludrocortisone 0.1 mg once daily. He has been unable to keep down his regular doses since yesterday. On examination he is drowsy but orientated, temperature 38.9°C, heart rate 118 beats per minute, blood pressure 82/56 mmHg lying, respiratory rate 22 breaths per minute, oxygen saturation 96% on air. He has dry mucous membranes and reduced skin turgor. Chest is clear, abdomen soft with mild epigastric tenderness, no peritonism. Initial investigations: sodium 126 mmol/L, potassium 5.5 mmol/L, urea 8.4 mmol/L, creatinine 1.0 mg/dL (eGFR 90 mL/min/1.73m²), glucose 5.2 mmol/L, blood cultures and urine culture sent. ECG shows sinus tachycardia. The patient has no known allergies and is not on any other regular medication. He does not have a steroid card with him. You are asked to prescribe the immediate management, including any intravenous fluids and corticosteroid therapy (if indicated). Consider the sick-day rules he will need later.
Your task
Past medical history: Primary adrenal insufficiency (Addison's disease) diagnosed 5 years ago. Current medications: hydrocortisone 10 mg oral each morning, 5 mg at midday, 5 mg in the evening; fludrocortisone 0.1 mg oral once daily. No known drug allergies. No other regular medication. No relevant family history.
What gets marked
- Whether you chose an indicated drug, and whether you avoided the contraindicated ones.
- Dose, route, frequency and duration against the range for this patient.
- Renal and hepatic dose adjustment where this patient's numbers demand it.
- Allergy cross-reactivity and interactions with the medicines already on the chart.
- The instructions and monitoring you write, not only the drug you pick.
8 scoring rules apply to this scenario. A single critical error fails the attempt whatever the score.
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Taught in
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Educational content for students and clinicians in training. It does not replace professional judgement, local protocols or current prescribing information.