Prescription Writing Practice

Addisonian Crisis in a Patient with Vomiting and Fever

Write a prescription for addisonian crisis and have every line marked: drug choice, dose, route, frequency and duration, checked against the patient's allergies, current medicines, renal function and the interaction database, with each error explained.

medium8 scoring rules

Patient
40 years, male, 75 kg
Diagnosis
Addisonian crisis
Renal function
eGFR 90 mL/min/1.73m²
Allergies
None known
Current medicines
hydrocortisone 10 mg in morning, 5 mg at midday and 5 mg in evening; fludrocortisone 0.1 mg once daily

The scenario

A 40-year-old man presents to the emergency department with a 24-hour history of vomiting and fever. He has known primary adrenal insufficiency (Addison's disease), diagnosed five years ago, and takes oral hydrocortisone 10 mg each morning, 5 mg at midday and 5 mg in the evening, with fludrocortisone 0.1 mg once daily. He has been unable to keep down his regular doses since yesterday. On examination he is drowsy but orientated, temperature 38.9°C, heart rate 118 beats per minute, blood pressure 82/56 mmHg lying, respiratory rate 22 breaths per minute, oxygen saturation 96% on air. He has dry mucous membranes and reduced skin turgor. Chest is clear, abdomen soft with mild epigastric tenderness, no peritonism. Initial investigations: sodium 126 mmol/L, potassium 5.5 mmol/L, urea 8.4 mmol/L, creatinine 1.0 mg/dL (eGFR 90 mL/min/1.73m²), glucose 5.2 mmol/L, blood cultures and urine culture sent. ECG shows sinus tachycardia. The patient has no known allergies and is not on any other regular medication. He does not have a steroid card with him. You are asked to prescribe the immediate management, including any intravenous fluids and corticosteroid therapy (if indicated). Consider the sick-day rules he will need later.

Your task

Past medical history: Primary adrenal insufficiency (Addison's disease) diagnosed 5 years ago. Current medications: hydrocortisone 10 mg oral each morning, 5 mg at midday, 5 mg in the evening; fludrocortisone 0.1 mg oral once daily. No known drug allergies. No other regular medication. No relevant family history.

What gets marked

  • Whether you chose an indicated drug, and whether you avoided the contraindicated ones.
  • Dose, route, frequency and duration against the range for this patient.
  • Renal and hepatic dose adjustment where this patient's numbers demand it.
  • Allergy cross-reactivity and interactions with the medicines already on the chart.
  • The instructions and monitoring you write, not only the drug you pick.

8 scoring rules apply to this scenario. A single critical error fails the attempt whatever the score.

Log in to prescribe for "Addisonian Crisis in a Patient with Vomiting and Fever"

A free account opens the prescription pad: search the formulary, write the chart, and have it marked line by line by the safety engine.

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Educational content for students and clinicians in training. It does not replace professional judgement, local protocols or current prescribing information.